PRODUCT WATCH |
Return of the devil
Dangerous drugs like thalidomide that were
banned for their toxicity have been re-incarnated to treat cancer and other diseases.
Labelled as a "miracle drug", thalidomide was known to be an effective
tranquilliser without any side effects. The drug was first synthesised by Ciba in 1953 to
treat anxiety and morning sickness in pregnant women. Marketed as Distaval, the drug was
banned in 1962 after scientists confirmed that it led to birth defects such as retardation
and deformed limbs. More than 12,000 children in 46 countries had been affected by then,
with only 8,000 of them surviving
past the first year of life. The actual mechanism of how the drug worked remains a mystery
.
Despite its ban in 1962, thalidomide has been on restricted sales
globally. It been prescribed for relief from painful lesions in leprosy, mouth and genital
ulcers and cancer. Dabur India has acquired the rights to manufacture and market
thalidomide to treat cancer and leprosy lesions. S Ganguly, senior clinical research
scientist at Dabur India, Sahibabad office, mentions that extreme precaution is being
taken to see that the drug is marketed to the right patient. It would be available only at
cancer institutions and accessible for leprologists from suffering leprosy patients. The
marketing is to be restricted to a few dealers who would be authorised to sell the drug
and who will maintain detailed records to track the prescribing doctors and the patient
alike. A 24-hour toll free help line will also be set up for patients
The marketing of thalidomide is going to be under close scrutiny by
consumer watchdogs. One slip and the horror would well be repeated. |
Heavily chipped
A study led by Eric Williams and his team at the United Nations University in Tokyo has
found that a 2 gramme microchip is equivalent to 1.6 kilogrammes of fossil fuel, 72
grammes of chemicals and 32 kilogrammes of water. Looking into all the chemicals including
coal, which are involved in turning raw quartz into a 32 MB RAM microchip, the team found
the chip manufacturing required more fuels and solvents because of its tiny size and the
need to keep it free from dirt and dust. Making a typical car required only about twice
its weight in fossil fuels. According to Eric Williams, "In order to produce one
memory chip that weighs two grams, the total amount of materials and fossil fuels required
to make that chip is 1,400 grams. Thats 700 times the weight of the original
chip." The environmental costs of manufacturing a chip thus far outweigh that of even
making a car. With new advances in technology and changing of computers every two years,
the environmental impact of owning a computer increases drastically.The focus now has to
shift from making chips that run on less power to manufacturing those that require less
energy than it does at the present.
Mercurial tempers
Each mercury fever thermometer when broken or thrown away is a threat to health. The
one-gram of mercury found in one thermometer is enough to pollute a 20-acre lake, says
Michael Bender, Director of the Mercury Policy Project, USA.
Mercury is used in lamps, batteries and electrical equipment, as well
as in thermometers and dental fillings. Concern over its presence in the atmosphere arises
since mercury is known to cause permanent damage to the brain, nervous system and kidneys.
Almost indestructible, mercury when put along with other waste into landfill sites, can
easily seep through the groundwater and from there into rivers, lakes and the sea. It can
also evaporate into the air, especially if the waste is incinerated.
Though mercury is produced naturally in rocks, soil and volcanoes,
industrialisation has boosted up the production of this heavy metal almost three times.
Almost 50 to 70 per cent of the 5,000 to 10,000 tonnes of mercury found in the atmosphere
is due to human activities. In its evaporated form, mercury can travel for thousands of
miles. Since it is know to accumulate in cold places high contamination levels of mercury
are to be found in Arctic regions, and especially among fish and animals there. In water,
mercury transforms naturally into methyl mercury, a highly toxic compound that gets
absorbed by humans and animals. Because it then accumulates up the food chain sea fishes
can accumulate large quantities of mercury in their tissue. Pregnant mothers and their
fetuses are particularly sensitive to the effects of mercury. According to the Centres for
Disease Control (CDC), Atlanta, USA, one-in-ten women of childbearing age have mercury
levels in their bodies above what is considered protective for a developing fetus.
Threatened children
A study conducted by Joseph Laquatra, associate professor of design and environmental
analysis in the New York State College of Human Ecology at Cornell, in the US, has found
children belonging to lower socio-economic status more prone to threats from indoor air
pollutants. Their houses have higher levels of radon, lead and mould than those occupied
by higher income households. If these children then spend the rest of the day exposed to
the same pollutants in a childcare facility, they are at a significantly higher risk for
falling sick due to lead poisoning, cancer, asthma attacks and allergies. Studying 328
houses and 75 childcare facilities in six nonmetropolitan counties of New York State,
homes of lower income residents were also found to contain higher levels of carbon
monoxide. Lack of an effective ventilation fan further aggravates the pollutant level.
These houses also had asbestos problems and presence of basement mould. Mould is a known
trigger for allergies and asthma. Exposure to lead, asbestos, radon and carbon monoxide
can lead to early death.
Cancer clusters
Factors like where a woman lives at birth and puberty may have an impact on her risk of
developing breast cancer later. A study conducted by Jo Freudenheim, professor in the
department of social and preventive medicine in the University of Buffalos school of
medicine and biomedical sciences, USA, finds that women who developed breast cancer were
more likely to have lived closer together at birth and at their first menstruation than
women who did not develop breast cancer. This suggests a possible linkage between breast
cancer and early environmental exposure to potential carcinogens.
Identifying these places and exposures is one way of proving these
linkages. In that respect, geographers and epidemiologists are working on a computerised
mapping programme wherein details about residential data along with the distance between
the surrounding environment comprising of steel mills, chemical factories, petrol pumps
and toxic waste sites that have been in the existence between the two counties between
1918-1980 will be weighed against with the birth and menarche details of the women. This
information will then be compared for women with or without cancer. Early data collected
and calculated reveals the greatest clustering of cancer cases at the time of menarche.
This could be because breast tissue may be more sensitive to environmental insults in
childhood and that exposures early in life could increase the risk of breast cancer in
adulthood.
Chernobyls
burden
On April 26 1986, the Chernobyl nuclear accident released vast amounts of radionuclides in
the environment. Various studies conducted over the period of time have focussed on the
increase of incidences of thyroid cancer and leukaemia in children. Evidence now suggests
that rates of thyroid cancer in children have risen as a consequence of Chernobyl
incident. The increase has been found to be the highest in children living close to the
area of the incident, especially Belarus. For 8 days after the accident, the entire
population of Belarus was exposed to Iodine 131. Iodine 131, when ingested, concentrates
in the thyroid gland and can cause thyroid cancer. The level of iodine 131 surpassed
permissible levels over 1,000 times. 170,000 children under 7 in the Chernobyl area
received radiation doses high enough to cause thyroid cancer.
Although less than five cases of thyroid
cancer in children were reported between 1986 and 1989, the number increased to 29 in
1990, 51 cases in 1991 and 62 in 1992. No such clear evidence has however been found in
the case of leukaemia. A new disease in the form of Chernobyl AIDS has
made its appearance wherein the radiation leads to the breakdown of the immune system,
loss of hearing and the build up of fluid in childrens heads.
Smoggy California
California is one of the smoggiest states of the USA. Tonnes of toxic emissions get
released each year in California. These emissions include a cocktail of industrial and
chemical solvents. This hazardous mixture can cause cancer, reproductive harm and
neurological damage. Children are most vulnerable. With the amount of pollutants present
in the air, a 18 year adolescent inhales enough contaminations to exceed the acceptable
exposure level by almost hundred times.
Children being more active inhale relatively more air than adults.
Since their immune system is also yet to be developed, their cells are more vulnerable to
attack by carcinogens. In Los Angeles alone, toxic air contaminants cause 720 cancer cases
per million people annually. The recent report of the EPA clearly shows that diesel
exhaust can cause cancer. The diesel health impact assessment report recently released
recommends reduction of tailpipe emissions by requiring cleaner-burning engines and
replacing diesel fuel with ultra-low sulphur content diesel. ``Overall, the evidence for a
potential cancer hazard to humans resulting from chronic inhalation exposure to (diesel
emissions) is persuasive, says the health impact report released by the EPA.
Heart risks
The September issue of Circulation: Journal of the American Heart Association reports on
how polluted air is more harmful for those suffering from heart diseases. According to
Juha Pekkanen, senior researcher at the National Public Health Institute, Unit of
Environmental Epidemiology in Kuopio, Finland, people with heart disease are about three
times more likely to have ischemia (decreased oxygen supply to heart muscle) during
exercise testing after being exposed to high level air pollution. The main culprit was
particulate matter having diameter less than 2.5 micrometers and even ultra-fine
particulate matter, having a diameter less than 0.1 micrometers.
Monitoring the electrocardiogram (ECG) of 41 residents of Helsinki,the
study found that 23 patients experienced exercise associated symptoms when air pollution
was high two days before a clinic visit. Avoiding outdoor exercise on hazy days could be
one way of staying off the risk of ischemia.
Plumbing matters
The corrosion of metallic plumbing materials carrying drinking water produces
environmental problems. Corrosion has an effect on the water quality, it changes the taste
of water and gives rise to unpleasant odour. It is the growth of microbes or leaching of
contaminants from the metallic, plastic or concrete plumbing that is a cause of concern.
Holes caused in water pipes due to corrosion allow the influx of contaminants into
drinking water systems.
Marc Edwards, professor of civil and environmental engineering at
Virginia Polytechnic Institute and State University, USA, is leading the research which
focuses on the health impacts caused due to corrosion of plumbing materials. How serious
the matter is can be gauged from the fact that the US will be spending about $ 325 billion
in the next 20 years to replace losses due to corrosion and to upgrade water distribution
systems.
Capital air
Delhi can now breathe easy. Stars can be seen in the sky. A 25 per cent reduction has been
noticed in pollution levels of the capital. According to Dilip Biswas, chairman of the
Central Pollution Control Board, average particulate matter in the air dropped to 347
microgrammes per cubic metre in 2001 as compared to 405 microgrammes in 2000. Sulphur
dioxide levels have come down to 14 microgrammes from 18 microgrammes and nitrogen dioxide
levels now stand at 34 microgrammes as against 36 microgrammes in 2000.
The phasing out of commercial vehicles older than 15 years in 1998,
coupled with switching over of majority of the vehicles to compressed natural gas (CNG)
and closing of thousands of chemicals and textile factories has helped Delhi breathe easy.
Vehicles alone in Delhi account for nearly 70 per cent of the pollution, while power
plants are responsible for 15 per cent and the remaining 10 per cent is contributed by the
various industries.
Killer weed
A recent study published in Environmental Health Perspectives talks of how a cocktail of
common herbicides may result in reduced fertility and cause miscarriages.The cocktail, a
mixture of 2,4-D, dicamba and mecoprop has been in the market after World War II. The
mixture is generally available as over the counter product. Studies done on crop workers
of Europe and Kansas show that farmers who work with 2,4-D have a higher rate of
non-Hodgkins lymphoma. The pesticide industry in the US has already spent more than 30$
million on 2,4-D toxicity trials. Studies conducted in wheat, sugar beet and potato
farming regions of USA have found twice the rate of birth defects among children of crop
workers who conceived the children during the months when the pesticide 2,4-D was sprayed.
Four cities study
The Chinese government and the US Environmental Protection Agency (EPA) recently conducted
an epidemiologic study of childrens and adults respiratory health in relation
to their exposure to both ambient as well as indoor air pollution in urban and suburban
districts of China.
Called the Four Chinese Cities Study, 7,621 school going children
residing in eight districts of Lanzhou, Chongqing, Wuhan and Guangzhou were covered. It
measured the ambient particulate matter present in these cities and also took into
consideration various risk factors like home environment, parental smoking, history of
parental asthma, having been breast-fed and gender.The prevalence rate for wheeze, asthma,
bronchitis,hospitalisation due to respiratory diseases, persistent cough, and persistent
phlegm was calculated.
Positive associations have been found between morbidity prevalence and
ambient levels of coarse particulate matter (PM) which range in the size of PM10-2.5. The
evidence of association between levels of nitrogen dioxide and sulphur dioxide and
childrens respiratory symptoms though present, is weaker than that of PM.
Immunological
exposures
The greatest risk of exposure to various petroleum derivatives is experienced by the
petrol filling station workers. Long term exposure to such derivatives is known to bring
out immunological changes in the workers. A two year period study was done on 89 male
petrol filling workers of Hyderabad and Secunderabad, belonging to the age group of 20-45
years and working for a period of 2-18 years.
The study measured the activity of serum adenosine deaminase (ADA),
which is an enzyme important for developing cell immunity. ADA activity increases during
the bodys imunnological responses. The research has been inspired by an earlier
study on the role of serum ADA activity in tobacco factory workers who were occupationally
exposed to tobacco dust and were found to have increased ADA activity as compared to
control group. A marginal increase in serum ADA activity of petrol filling stations
workers has been reported in this study but the research calls for further insights to
substantiate the findings.
Tylenol blues
Tylenol, the most popular non-prescription drug of the US has been found to have an
important role to play in causing liver damage. Study conducted over a period of 25 years
by the Food and Drug Administration (FDA) advisory panel shows that acetaminophen, the
active ingredient in Tylenol causes liver disease. More than 50 million Americans use
Tylenol every year. How much of it is safe and can small doses also be toxic is the
question now being asked. Says Kate Trunk of the FDA, " You cannot allow more
innocent men, women and children to suffer." Her own son died from liver disease
after taking acetaminophen drug on injuring his wrist.
The drug manufactured by Johnson & Johnson (J & J) carries no
reference about its potential side effects on its packaging. On the contrary, its campaign
once boasted of "nothing's safer" but the reality now is something different.
Over dose of acetaminophen in itself is responsible for more than
56,000 emergency room visits every year in the USA, with more than 100 being fatal.
According to William Lee of the university of Texas Southwestern Medical Centre,
acetaminophen is the leading cause of liver failure. Treatment of tylenol related cases is
rarely successful. After a while, J & J included a warning with each adult Tylenol
package noting that the liver damage could be due to the mixing of the drug with alcohol
and the drug by itself was safe.
For the warning to become mandatory, the FDA has to formally adopt the
recommendation.
Poisoned fragrance
Lead is added to candle wicks to stiffen them and to let them burn for longer time.
Burning a leaded-wick candle raises the level of particulate matter not just near the
candle but also throughout the room and even the house. The study conducted by Shirley
Wasson and her team and reported in the June issue of New Scientist suggests that
just four hours of burning of one average leaded-wick candle will raise the lead levels to
6.2 microgrammes per cubic metre (µg/m3) in the room with the candle and to 2 µg/m3
throughout the rest of the house. The US National Air Quality Standard for lead set by the
Environmental Protection Agency (EPA) is 1.5 µg/m3. Since 1992, US import of lead candles
has risen by 800 per cent. More than 3 million lead wick candles are sold every year in
the US alone. A safer though expensive alternative would be that of using zinc instead of
lead in wicks.
Asthma
research
Concerned over the increase in the number of children with asthma, the US Environmental
Protection Agency (EPA) and the American Lung Association have launched the Asthma
Research Strategy, which would discuss future research efforts and address specific
issues.
The research would be used to devise appropriate strategies to control
environmental factors that exacerbate asthma. According to the EPA, the year 2001 saw
around 3.8 million children being affected by asthma attack. Most of these attacks were
triggered by environmental contaminants like particulate matter, smoke, air pollution, and
pollen.
The Asthma Research Strategy aims to set standards that would aim to
protect children prone towards asthma attack. It would be discussing future research
efforts and addressing issues likefactors which contribute to the induction and
exacerbation of asthma (biomass smoke, air pollutants), susceptibility factors (genetics,
socio-economic status, health, type of housing, and lifestyle patterns) and assessing the
management of environmental pollutants which are relevant to asthma.