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March-April 2005
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BRIEFS

Dyed food

Dyed foodThe Food Standards Agency (FSA) of Britain has warned people against more than 350 food items that contain a carcinogenic dye called Sudan 1. The illegally used dye was found in a batch of chilli powder used by a British tea and pickle-maker, Premier Foods, to make Worcester sauce. Presently, investigations are being carried out to find how the chilli powder was contaminated before it was supplied to the sauce manufacturer. FSA has published a list of 359 products that may have used the sauce in question and advised the public not to eat them. The same agency had issued a warning in December 2003 on Sudan 1 contamination of another International Brand in ginger-garlic spice mix. Since then, the use of this dye had been banned in food products.

Sudan 1 is a red dye normally used as a colouring agent in solvents, oils, waxes, petrol, and shoe and floor polish. A study by the German Cancer Research Centre in 2002 confirmed that Sudan 1 could cause cancer of liver and urinary bladder among humans.

Following this, more than 418 food products have been withdrawn from the Britain’s supermarkets. But the Indian market continues to sell these products. According to the government, “The Spices Board had imposed very stringent norms about colouring agents, and the chillies supplied to the European Union did not have any cancer-causing substances.” Another fact worth noting is that India is the chief exporter of spices to the world. The presence of carcinogen-laden dye in the spices puts a question mark on the monitoring of these ingredients. Food companies in the UK have admitted that the adulterated chilli powder added to the sauce had been used in food sent to hospitals and schools. FSA is still trying to track who has been responsible for adulteration or whether anyone should be prosecuted for it.

Sources: 1. Anon 2005, Cancer risk warning in UK, in The Indian Express, New Delhi, February 19.
2. Marie Stiborová et al 2002, Sudan I Is a potential car-cinogen for humans, evidence for Its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes, in Cancer Research, Vol 62, pp 5678-5684.



Nineteen years after Chernobyl

Since the 1986 Chernobyl (Ukraine) nuclear reactor accident, incidence of thyroid cancer is steadily on rise in the neighbouring country of Republic of Belarus. A report to this effect has been published by Martin Mahoney of Roswell Cancer Institute, Buffalo, USA, in 2004 in the International Journal of Epidemiology. Between 1970 and 2001, age-adjusted thyroid cancer incidence rates have increased from 0.4 per lakh to 3.5 per lakh populace among men and from 0.8 per lakh to 16.2 per lakh populace among women. The increase in cancer cases was remarkable for both sexes after the accident and was found in both ‘high exposure’ (regions closer to the nuclear plant) and ‘low exposure’ (regions far off from the reactor site) areas. But the relative increases in the ‘high exposure’ area from the Chernobyl disaster exceeded those in the ‘low exposure’ areas, with marked increases in thyroid cancer incidence rate ratios between both genders and in all age groups. Lower age at the time of radiation exposure was  thought to be a factor behind increased susceptibility as a result of higher radiation doses per unit of thyroid tissue and higher metabolic activity of the thyroid gland relative to adults. Highest increases were observed among children from ‘higher exposure’ areas in the age group 0-14 years at the time of diagnosis. Furthermore, there were more atypical thyroid cancer incidences among the children exposed to radiation at the age of two or less, which was presumed to be radiogenic. Pre-existing iodine deficiency in the region coupled with radiation exposure doubled the risk of developing thyroid cancer in children and adolescents. Women showed notable increase in thyroid cancer compared to men. These radiations cause damage to deoxyribonucleic acid and trigger uncontrolled cell division, resulting in cancers in thyroid, lung, breast and blood.

Source: Martin C Mahoney 2004, Thyroid cancer incidence trends in Belarus: examining the impact of Chernobyl, in International Journal of Epidemiology, Vol 33, No 5, pp 1025-1033.

Before time

Preterm birth is the leading cause of infant mortality in industrialised countries. Adverse pregnancy outcomes are more frequent among socially dis-advantaged women. Following the introduction of economic and political reforms in Russia in 1991, majority of the population became impoverished. There was a considerable decline in the overall life expectancy and an increase in the social and health inequalities. The proportion of infants born before term increased in many industrialised countries during the same time span. For instance, preterm birth rates increased from 9.4 per cent in 1981 to 11.9 per cent in 2001 in the US. A study was conducted by Grjibovski and his co-workers from Karolinska Institute in Severodvinsk, a town in Russia in 1999. All pregnant women registered at prenatal care centres in the town were enrolled for the study. Data on maternal education, occupation, marital status, pre-pregnancy weight, gestational length and pregnancy out-comes was obtained from the medical records of the maternity homes. Data on maternal reproductive history and complications was also abstracted from the records. Statistical analysis of the data revealed that maternal education was significantly associated with the period of gestation and spontaneous preterm birth. A low level of education among the women was associated with the risk of preterm birth. Mothers aged more than 30 years were also at increased risk of preterm delivery. Two mechanisms to explain social disparities in preterm birth were proposed. The first involves unhealthy behaviours, infections, exposure to stress and physiological reactions to these factors that shorten gestation. The second one involves gene and environment interaction resulting in a structural change of the former. Economic crisis in Russia led to poor compliance with the medical recommendations on diet and vitamin supplementation.

Source: A M Grjibovski et al 2005, Large social disparities in spontaneous preterm birth rates in transitional Russia, in Public Health, The Royal Institute of Public Health, USA, Vol 119, pp 77-86.

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